| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphoethanolamine N-methyltransferase |
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| Ligand | BDBM50462274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1774479 (CHEMBL4231471) |
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| IC50 | 44300±n/a nM |
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| Citation |  Vallone, A; D'Alessandro, S; Brogi, S; Brindisi, M; Chemi, G; Alfano, G; Lamponi, S; Lee, SG; Jez, JM; Koolen, KJM; Dechering, KJ; Saponara, S; Fusi, F; Gorelli, B; Taramelli, D; Parapini, S; Caldelari, R; Campiani, G; Gemma, S; Butini, S Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues. Eur J Med Chem150:698-718 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphoethanolamine N-methyltransferase |
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| Name: | Phosphoethanolamine N-methyltransferase |
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| Synonyms: | PMT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31038.21 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_829173 |
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| Residue: | 266 |
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| Sequence: | MTLIENLNSDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVL
DIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEANDILTKEFPENN
FDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDYCATEKENWDDEFKEYVKQRK
YTLITVEEYADILTACNFKNVVSKDLSDYWNQLLEVEHKYLHENKEEFLKLFSEKKFISL
DDGWSRKIKDSKRKMQRWGYFKATKN
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| BDBM50462274 |
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| n/a |
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| Name | BDBM50462274 |
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| Synonyms: | CHEMBL4246869 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25ClN2O |
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| Mol. Mass. | 380.91 |
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| SMILES | Clc1ccc(-c2ccc(CNCC3CCNCC3)o2)c(c1)-c1ccccc1 |
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| Structure | 
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