| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase subunit gamma-1 |
|---|
| Ligand | BDBM50244667 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1777649 (CHEMBL4234641) |
|---|
| EC50 | >40000±n/a nM |
|---|
| Citation |  Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem61:7273-7288 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5'-AMP-activated protein kinase subunit gamma-1 |
|---|
| Name: | 5'-AMP-activated protein kinase subunit gamma-1 |
|---|
| Synonyms: | 5'-AMP-activated protein kinase subunit gamma-1 | AAKG1_HUMAN | AMP-activated protein kinase, gamma-1 subunit | AMPK alpha2/beta2/gamma1 | AMPK gamma-1 | AMPK gamma1 | AMPK subunit gamma-1 | AMPKg | PRKAG1 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 37581.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P54619 |
|---|
| Residue: | 331 |
|---|
| Sequence: | METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKA
FFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREV
YLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFI
TEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDI
YSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL
VVVDENDVVKGIVSLSDILQALVLTGGEKKP
|
|
|
|---|
| BDBM50244667 |
|---|
| n/a |
|---|
| Name | BDBM50244667 |
|---|
| Synonyms: | CHEMBL4105032 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17F2NO3 |
|---|
| Mol. Mass. | 357.3507 |
|---|
| SMILES | OC(=O)c1c[nH]c2cc(F)c(-c3ccc(cc3)[C@@H]3CCCCO3)c(F)c12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
