| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase subunit beta-2 |
|---|
| Ligand | BDBM50463099 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1777629 (CHEMBL4234621) |
|---|
| EC50 | >40000±n/a nM |
|---|
| Citation |  Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem61:7273-7288 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5'-AMP-activated protein kinase subunit beta-2 |
|---|
| Name: | 5'-AMP-activated protein kinase subunit beta-2 |
|---|
| Synonyms: | AAKB2_HUMAN | AMPK alpha2/beta2/gamma3 | AMPK subunit beta-2 | PRKAB2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30301.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107883 |
|---|
| Residue: | 272 |
|---|
| Sequence: | MGNTTSDRVSGERHGAKAARSEGAGGHAPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFV
SWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPE
GEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRD
LSSSPPGPYGQEMYAFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNH
LYALSIKDSVMVLSATHRYKKKYVTTLLYKPI
|
|
|
|---|
| BDBM50463099 |
|---|
| n/a |
|---|
| Name | BDBM50463099 |
|---|
| Synonyms: | CHEMBL4246000 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25F2NO9 |
|---|
| Mol. Mass. | 533.4748 |
|---|
| SMILES | O[C@@H]1[C@@H](O)[C@H](OC(=O)c2c[nH]c3cc(F)c(c(F)c23)-c2ccc(cc2)[C@@H]2CCCCO2)O[C@@H]([C@H]1O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
