| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group I member 2 |
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| Ligand | BDBM50463440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1778217 (CHEMBL4235209) |
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| EC50 | 4200±n/a nM |
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| Citation |  Toyama, H; Shirakawa, H; Komai, M; Hashimoto, Y; Fujii, S Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity. Bioorg Med Chem26:4493-4501 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 1 group I member 2 |
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| Name: | Nuclear receptor subfamily 1 group I member 2 |
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| Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
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| Type: | Nuclear receptor |
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| Mol. Mass.: | 49774.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75469 |
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| Residue: | 434 |
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| Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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| BDBM50463440 |
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| n/a |
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| Name | BDBM50463440 |
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| Synonyms: | CHEMBL4247454 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23NO4SSi |
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| Mol. Mass. | 365.519 |
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| SMILES | [#6]-[#8]-[#6]-[#6]-[#7](-c1ccc(cc1)[Si;v4]([#6])([#6])[#8])S(=O)(=O)c1ccccc1 |
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| Structure | 
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