| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase CSK |
|---|
| Ligand | BDBM50463479 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1778347 (CHEMBL4235339) |
|---|
| Ki | >2000±n/a nM |
|---|
| Citation |  Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors. Bioorg Med Chem Lett28:2622-2626 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase CSK |
|---|
| Name: | Tyrosine-protein kinase CSK |
|---|
| Synonyms: | C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK |
|---|
| Type: | Tyrosine-protein kinase |
|---|
| Mol. Mass.: | 50707.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41240 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
NCWHLDAAMRPSFLQLREQLEHIKTHELHL
|
|
|
|---|
| BDBM50463479 |
|---|
| n/a |
|---|
| Name | BDBM50463479 |
|---|
| Synonyms: | CHEMBL4249925 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17N5O3S2 |
|---|
| Mol. Mass. | 427.5 |
|---|
| SMILES | CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
