| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase TXK |
|---|
| Ligand | BDBM165209 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1778712 (CHEMBL4235704) |
|---|
| IC50 | 2.3±n/a nM |
|---|
| Citation |  Liu, Q; Batt, DG; Chaudhry, C; Lippy, JS; Pattoli, MA; Surti, N; Xu, S; Carter, PH; Burke, JR; Tino, JA Conversion of carbazole carboxamide based reversible inhibitors of Bruton's tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series. Bioorg Med Chem Lett28:3080-3084 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase TXK |
|---|
| Name: | Tyrosine-protein kinase TXK |
|---|
| Synonyms: | PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 61268.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P42681 |
|---|
| Residue: | 527 |
|---|
| Sequence: | MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
|
|
|
|---|
| BDBM165209 |
|---|
| n/a |
|---|
| Name | BDBM165209 |
|---|
| Synonyms: | US10604504, Example 34 | US11623921, Example 34 | US9688629, 34 | US9802915, Example 34 | US9920031, Example 34 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21N3O3S |
|---|
| Mol. Mass. | 383.464 |
|---|
| SMILES | Cc1[nH]c2c(ccc(-c3cccc(NS(=O)(=O)C=C)c3C)c2c1C)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
