| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM50464790 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1782645 (CHEMBL4254162) |
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| IC50 | 0.750000±n/a nM |
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| Citation |  Ling, Y; Guo, J; Yang, Q; Zhu, P; Miao, J; Gao, W; Peng, Y; Yang, J; Xu, K; Xiong, B; Liu, G; Tao, J; Luo, L; Zhu, Q; Zhang, Y Development of novel ?-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells. Eur J Med Chem144:398-409 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM50464790 |
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| n/a |
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| Name | BDBM50464790 |
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| Synonyms: | CHEMBL4288953 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22N4O2 |
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| Mol. Mass. | 422.4785 |
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| SMILES | Cc1ccc(cc1)-c1nc(NCc2ccc(cc2)C(=O)NO)cc2c3ccccc3[nH]c12 |
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| Structure | 
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