Reaction Details |
| Report a problem with these data |
Target | Calpain-1 catalytic subunit |
---|
Ligand | BDBM50465145 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1784251 (CHEMBL4255768) |
---|
Ki | 490±n/a nM |
---|
Citation | Kling, A; Jantos, K; Mack, H; Hornberger, W; Backfisch, G; Lao, Y; Nijsen, M; Rendenbach-Mueller, B; Moeller, A Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1' Extension. ACS Med Chem Lett9:221-226 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Calpain-1 catalytic subunit |
---|
Name: | Calpain-1 catalytic subunit |
Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
Type: | Protein |
Mol. Mass.: | 81880.51 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 714 |
Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
|
|
|
BDBM50465145 |
---|
n/a |
---|
Name | BDBM50465145 |
Synonyms: | CHEMBL4284950 |
Type | Small organic molecule |
Emp. Form. | C29H27N5O3 |
Mol. Mass. | 493.5564 |
SMILES | O=C(NC1CCC1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(n1)-c1ccccc1 |
Structure |
|