| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine--tRNA ligase |
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| Ligand | BDBM50465344 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1784613 (CHEMBL4256130) |
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| IC50 | >100±n/a nM |
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| Citation |  Gao, JB; Yang, SJ; Yan, ZR; Zhang, XJ; Pu, DB; Wang, LX; Li, XL; Zhang, RH; Xiao, WL Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. J Nat Prod81:998-1006 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine--tRNA ligase |
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| Name: | Lysine--tRNA ligase |
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| Synonyms: | KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68044.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_960665 |
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| Residue: | 597 |
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| Sequence: | MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
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| BDBM50465344 |
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| n/a |
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| Name | BDBM50465344 |
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| Synonyms: | CHEMBL4294902 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24O4 |
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| Mol. Mass. | 316.3915 |
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| SMILES | [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@]2(CO)C(O)=O)C(C)=O |r| |
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| Structure | 
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