Reaction Details |
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Target | WD repeat-containing protein 5 |
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Ligand | BDBM50465555 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1785272 (CHEMBL4256789) |
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Ki | 8.4±n/a nM |
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Citation | Wang, F; Jeon, KO; Salovich, JM; Macdonald, JD; Alvarado, J; Gogliotti, RD; Phan, J; Olejniczak, ET; Sun, Q; Wang, S; Camper, D; Yuh, JP; Shaw, JG; Sai, J; Rossanese, OW; Tansey, WP; Stauffer, SR; Fesik, SW Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J Med Chem61:5623-5642 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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WD repeat-containing protein 5 |
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Name: | WD repeat-containing protein 5 |
Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
Type: | Protein |
Mol. Mass.: | 36597.13 |
Organism: | Homo sapiens (Human) |
Description: | P61964 |
Residue: | 334 |
Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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BDBM50465555 |
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n/a |
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Name | BDBM50465555 |
Synonyms: | CHEMBL4287817 |
Type | Small organic molecule |
Emp. Form. | C25H27N3O2 |
Mol. Mass. | 401.5008 |
SMILES | COc1cc(CC(=O)N[C@@H]2CCc3ccc(cc23)-c2cn3CCCc3n2)ccc1C |r| |
Structure |
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