| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Free fatty acid receptor 1 |
|---|
| Ligand | BDBM50466518 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1793287 (CHEMBL4265206) |
|---|
| EC50 | 150±n/a nM |
|---|
| Citation |  Guo, B; Guo, S; Huang, J; Li, J; Li, J; Chen, Q; Zhou, X; Xie, X; Yang, Y Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles. Bioorg Med Chem26:5780-5791 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Free fatty acid receptor 1 |
|---|
| Name: | Free fatty acid receptor 1 |
|---|
| Synonyms: | FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 31473.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14842 |
|---|
| Residue: | 300 |
|---|
| Sequence: | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLP
LKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRP
CYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAG
PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPY
NASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
|
|
|
|---|
| BDBM50466518 |
|---|
| n/a |
|---|
| Name | BDBM50466518 |
|---|
| Synonyms: | CHEMBL4283222 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18Cl2O5 |
|---|
| Mol. Mass. | 421.271 |
|---|
| SMILES | CC#C[C@@H](CC(O)=O)c1ccc(OC[C@H]2COc3cc(Cl)c(Cl)cc3O2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
