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TargetPoly(ADP-ribose) glycohydrolase
LigandBDBM50466568
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1793403 (CHEMBL4265322)
EC50>70000±n/a nM
Citation Waszkowycz, BSmith, KMMcGonagle, AEJordan, AMActon, BFairweather, EEGriffiths, LAHamilton, NMHamilton, NSHitchin, JRHutton, CPJames, DIJones, CDJones, SMould, DPSmall, HFStowell, AIJTucker, JAWaddell, IDOgilvie, DJ Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides. J Med Chem61:10767-10792 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Poly(ADP-ribose) glycohydrolase
Name:Poly(ADP-ribose) glycohydrolase
Synonyms:PARG | PARG_HUMAN | Poly(ADP-ribose) glycohydrolase | poly(ADP-ribose) glycohydrolase (PARG)
Type:Protein
Mol. Mass.:111107.13
Organism:Homo sapiens (Human)
Description:Q86W56
Residue:976
Sequence:
MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT
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  Blast E-value cutoff:
BDBM50466568
n/a
NameBDBM50466568
Synonyms:CHEMBL4288328
TypeSmall organic molecule
Emp. Form.C21H13Cl3N2O4S2
Mol. Mass.527.828
SMILESOC(=O)CCN1C(=S)S\C(C1=O)=C1/C(=O)N(Cc2c(Cl)cccc2Cl)c2ccc(Cl)cc12
Structure
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