Reaction Details |
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Target | Serine/threonine-protein kinase B-raf |
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Ligand | BDBM50468557 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1799947 (CHEMBL4272239) |
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IC50 | 10.0±n/a nM |
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Citation | Li, HL; Su, MM; Xu, YJ; Xu, C; Yang, YS; Zhu, HL Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAF Eur J Med Chem155:725-735 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase B-raf |
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Name: | Serine/threonine-protein kinase B-raf |
Synonyms: | B-raf | BRAF_MOUSE | Braf | Proto-oncogene B-Raf | Serine/threonine-protein kinase B-raf |
Type: | PROTEIN |
Mol. Mass.: | 88789.83 |
Organism: | Mus musculus |
Description: | ChEMBL_105657 |
Residue: | 804 |
Sequence: | MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAI
PEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESL
VFQTPTDASRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCA
VYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLF
QGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSGS
SSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPV
NIDEKFPEVELQDQRDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDF
EPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSEDRSRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVG
VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG
MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS
NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDF
SLYACASPKTPIQAGGYGEFAAFK
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BDBM50468557 |
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n/a |
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Name | BDBM50468557 |
Synonyms: | CHEMBL4294787 |
Type | Small organic molecule |
Emp. Form. | C31H27N3O3S |
Mol. Mass. | 521.629 |
SMILES | S=C(Nc1ccccc1)N1N=C(CC1c1ccc2OCCOc2c1)c1ccc(OCc2ccccc2)cc1 |c:11| |
Structure |
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