| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
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| Ligand | BDBM50468570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1799947 (CHEMBL4272239) |
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| IC50 | 50±n/a nM |
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| Citation |  Li, HL; Su, MM; Xu, YJ; Xu, C; Yang, YS; Zhu, HL Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAF Eur J Med Chem155:725-735 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase B-raf |
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| Name: | Serine/threonine-protein kinase B-raf |
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| Synonyms: | B-raf | BRAF_MOUSE | Braf | Proto-oncogene B-Raf | Serine/threonine-protein kinase B-raf |
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| Type: | PROTEIN |
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| Mol. Mass.: | 88789.83 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_105657 |
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| Residue: | 804 |
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| Sequence: | MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAI
PEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESL
VFQTPTDASRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCA
VYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLF
QGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSGS
SSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPV
NIDEKFPEVELQDQRDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDF
EPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSEDRSRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVG
VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG
MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS
NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDF
SLYACASPKTPIQAGGYGEFAAFK
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| BDBM50468570 |
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| n/a |
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| Name | BDBM50468570 |
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| Synonyms: | CHEMBL4290513 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20BrN3O2S |
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| Mol. Mass. | 494.404 |
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| SMILES | Brc1ccc(cc1)C1=NN(C(C1)c1ccc2OCCOc2c1)C(=S)Nc1ccccc1 |t:8| |
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| Structure | 
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