Reaction Details |
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Target | Zinc finger protein GLI1 |
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Ligand | BDBM50468715 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1800974 (CHEMBL4273266) |
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IC50 | 39200±n/a nM |
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Citation | Berardozzi, S; Bernardi, F; Infante, P; Ingallina, C; Toscano, S; De Paolis, E; Alfonsi, R; Caimano, M; Botta, B; Mori, M; Di Marcotullio, L; Ghirga, F Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold. Eur J Med Chem156:554-562 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Zinc finger protein GLI1 |
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Name: | Zinc finger protein GLI1 |
Synonyms: | GLI1_MOUSE | Gli | Gli1 | Glioma-associated oncogene homolog |
Type: | PROTEIN |
Mol. Mass.: | 118579.34 |
Organism: | Mus musculus |
Description: | EBI_101259 |
Residue: | 1111 |
Sequence: | MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETS
SCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSP
GGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATC
QLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDC
RWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTG
EKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHS
NEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKRE
REGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDL
SSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVS
LDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARG
SGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFK
SLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLN
PYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPEN
WGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSE
GSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLV
CNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPA
SANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPE
VGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTP
SPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
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BDBM50468715 |
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n/a |
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Name | BDBM50468715 |
Synonyms: | CHEMBL4289866 |
Type | Small organic molecule |
Emp. Form. | C25H22O6 |
Mol. Mass. | 418.4386 |
SMILES | COc1cc(OC)c2c(c1)occ(-c1ccc(OCc3ccccc3)c(OC)c1)c2=O |
Structure |
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