Reaction Details |
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Target | DNA topoisomerase 4 subunit B |
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Ligand | BDBM50470397 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1802726 (CHEMBL4275018) |
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IC50 | 400±n/a nM |
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Citation | Ho, SY; Wang, W; Ng, FM; Wong, YX; Poh, ZY; Tan, SWE; Ang, SH; Liew, SS; Joyner Wong, YS; Tan, Y; Poulsen, A; Pendharkar, V; Sangthongpitag, K; Manchester, J; Basarab, G; Hill, J; Keller, TH; Cherian, J Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. Eur J Med Chem157:610-621 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA topoisomerase 4 subunit B |
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Name: | DNA topoisomerase 4 subunit B |
Synonyms: | DNA Topoisomerase IV Subunit B | DNA topoisomerase 4 subunit B (parE) | PARE_ECOLI | nfxD | parE |
Type: | Enzyme Subunit |
Mol. Mass.: | 70233.03 |
Organism: | Escherichia coli (strain K12) |
Description: | n/a |
Residue: | 630 |
Sequence: | MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILH
ADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVN
ALSKRVEVNVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFS
VSRLTHVLKAKAVLCPGVEITFKDEINNTEQRWCYQDGLNDYLAEAVNGLPTLPEKPFIG
NFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNI
LPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFILWLNQ
NVQAAELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGD
SAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQL
RYGKICILADADSDGLHIATLLCALFVKHFRALVKHGHVYVALPPLYRIDLGKEVYYALT
EEEKEGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTIDDEDDQRTD
AMMDMLLAKKRSEDRRNWLQEKGDMAEIEV
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BDBM50470397 |
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n/a |
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Name | BDBM50470397 |
Synonyms: | CHEMBL4294536 |
Type | Small organic molecule |
Emp. Form. | C25H25F3N8OS |
Mol. Mass. | 542.579 |
SMILES | CCNC(=O)Nc1cc(-c2nc(cs2)C(F)(F)F)c(cn1)-c1cc2ncccc2nc1N1CCN(C)CC1 |
Structure |
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