Reaction Details |
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Target | DNA gyrase subunit B |
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Ligand | BDBM50006565 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1802725 (CHEMBL4275017) |
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IC50 | 6±n/a nM |
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Citation | Ho, SY; Wang, W; Ng, FM; Wong, YX; Poh, ZY; Tan, SWE; Ang, SH; Liew, SS; Joyner Wong, YS; Tan, Y; Poulsen, A; Pendharkar, V; Sangthongpitag, K; Manchester, J; Basarab, G; Hill, J; Keller, TH; Cherian, J Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. Eur J Med Chem157:610-621 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA gyrase subunit B |
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Name: | DNA gyrase subunit B |
Synonyms: | DNA gyrase subunit B | DNA gyrase subunit B (gyrB) | GYRB_ECOLI | Type IIA topoisomerase subunit GyrB | acrB | cou | gyrB | himB | hisU | nalC | parA | pcbA |
Type: | Enzyme Subunit |
Mol. Mass.: | 89941.28 |
Organism: | Escherichia coli (strain K12) |
Description: | P0AES6 |
Residue: | 804 |
Sequence: | MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEII
VTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGV
SVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVT
EFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNI
FYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKE
GYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEY
LLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSEL
YLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGR
DEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKG
KQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERR
YPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLF
EPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFE
QALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTL
MGDAVEPRRAFIEENALKAANIDI
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BDBM50006565 |
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n/a |
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Name | BDBM50006565 |
Synonyms: | CHEMBL3235085 |
Type | Small organic molecule |
Emp. Form. | C18H14F3N5O3S |
Mol. Mass. | 437.396 |
SMILES | CCNC(=O)Nc1cc(-c2nc(cs2)C(F)(F)F)c(cn1)-c1cncc(c1)C(O)=O |
Structure |
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