| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TBK1 |
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| Ligand | BDBM357909 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1803718 (CHEMBL4276010) |
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| IC50 | 302±n/a nM |
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| Citation |  Beyett, TS; Gan, X; Reilly, SM; Gomez, AV; Chang, L; Tesmer, JJG; Saltiel, AR; Showalter, HD Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK? for the treatment of obesity. Bioorg Med Chem26:5443-5461 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase TBK1 |
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| Name: | Serine/threonine-protein kinase TBK1 |
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| Synonyms: | NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN |
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| Type: | protein |
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| Mol. Mass.: | 83645.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UHD2 |
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| Residue: | 729 |
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| Sequence: | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
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| BDBM357909 |
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| n/a |
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| Name | BDBM357909 |
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| Synonyms: | 2-Amino-8-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid | US10214536, Compound 258 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14N2O4 |
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| Mol. Mass. | 298.2934 |
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| SMILES | CC(C)c1ccc2c(c1)oc1nc(N)c(cc1c2=O)C(O)=O |
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| Structure | 
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