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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein kinase C theta type | ||
| Ligand | BDBM50469258 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1803798 (CHEMBL4276090) | ||
| IC50 | 4.6±n/a nM | ||
| Citation |  Kunikawa, S; Tanaka, A; Takasuna, Y; Tasaki, M; Chida, N A novel 2,4-diaminopyrimidine derivative as selective inhibitor of protein kinase C theta prevents allograft rejection in a rat heart transplant model. Bioorg Med Chem26:5499-5509 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein kinase C theta type | |||
| Name: | Protein kinase C theta type | ||
| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 81878.04 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). | ||
| Residue: | 706 | ||
| Sequence: |
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| BDBM50469258 | |||
| n/a | |||
| Name | BDBM50469258 | ||
| Synonyms: | CHEMBL4294119 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H21BrN6 | ||
| Mol. Mass. | 401.304 | ||
| SMILES | N[C@H]1CC[C@H](CNc2nc(Nc3cccc(Br)c3)ncc2C#N)CC1 |r,wU:1.0,wD:4.4,(42.78,-14.37,;42.78,-15.91,;44.12,-16.68,;44.12,-18.22,;42.79,-18.99,;42.8,-20.54,;44.13,-21.29,;44.14,-22.83,;42.82,-23.61,;42.82,-25.15,;41.49,-25.92,;40.15,-25.16,;40.15,-23.62,;38.81,-22.86,;37.48,-23.63,;37.49,-25.17,;36.16,-25.95,;38.82,-25.94,;44.15,-25.92,;45.49,-25.14,;45.48,-23.6,;46.81,-22.83,;48.14,-22.05,;41.45,-18.23,;41.45,-16.69,)| | ||
| Structure | 
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