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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50469358 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1804040 (CHEMBL4276332) | ||
| IC50 | 2.5±n/a nM | ||
| Citation |  Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM50469358 | |||
| n/a | |||
| Name | BDBM50469358 | ||
| Synonyms: | CHEMBL4277564 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H46N6O | ||
| Mol. Mass. | 506.7258 | ||
| SMILES | CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CNCCN(CC)CC)cc1 |r,wU:13.12,wD:16.16,3.3,(2.68,-16.5,;4.01,-15.73,;5.34,-16.5,;6.68,-15.73,;6.68,-14.19,;8.01,-16.5,;9.34,-15.73,;9.35,-14.19,;10.67,-13.42,;12.01,-14.18,;13.49,-13.7,;14.4,-14.95,;13.49,-16.21,;14.23,-17.55,;15.77,-17.58,;16.51,-18.93,;15.71,-20.25,;16.46,-21.6,;14.17,-20.21,;13.44,-18.87,;12.01,-15.73,;10.68,-16.5,;14.2,-12.34,;15.74,-12.28,;16.45,-10.91,;15.63,-9.61,;16.34,-8.25,;17.89,-8.19,;18.71,-9.49,;20.25,-9.43,;21.07,-10.73,;20.36,-12.09,;18.82,-12.15,;22.61,-10.66,;23.33,-9.3,;14.08,-9.68,;13.37,-11.05,)| | ||
| Structure | 
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