Reaction Details | |||
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Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM50469360 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1804040 (CHEMBL4276332) | ||
IC50 | 1.2±n/a nM | ||
Citation | Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM50469360 | |||
n/a | |||
Name | BDBM50469360 | ||
Synonyms: | CHEMBL4289301 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H37N7O | ||
Mol. Mass. | 463.6183 | ||
SMILES | CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccnc(c1)N1CCNCC1 |r,wU:13.12,wD:16.16,3.3,(4.25,-14.92,;5.58,-14.16,;6.91,-14.93,;8.25,-14.16,;8.25,-12.62,;9.58,-14.93,;10.91,-14.16,;10.92,-12.61,;12.25,-11.84,;13.58,-12.61,;15.06,-12.13,;15.97,-13.38,;15.06,-14.64,;15.8,-15.98,;17.34,-16,;18.08,-17.36,;17.29,-18.68,;18.03,-20.03,;15.75,-18.64,;15.01,-17.3,;13.58,-14.16,;12.25,-14.93,;15.77,-10.76,;14.94,-9.47,;15.65,-8.11,;17.2,-8.04,;18.02,-9.34,;17.31,-10.71,;19.56,-9.28,;20.38,-10.58,;21.91,-10.52,;22.64,-9.16,;21.81,-7.86,;20.27,-7.91,)| | ||
Structure |