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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50469350 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1804040 (CHEMBL4276332) | ||
| IC50 | 4.9±n/a nM | ||
| Citation |  Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
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| BDBM50469350 | |||
| n/a | |||
| Name | BDBM50469350 | ||
| Synonyms: | CHEMBL4284846 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H31N5O3 | ||
| Mol. Mass. | 437.5346 | ||
| SMILES | CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccnc(c1)C(=O)OC |r,wU:13.12,wD:16.16,3.3,(1.51,-9.85,;2.84,-9.08,;4.18,-9.86,;5.51,-9.09,;5.51,-7.55,;6.84,-9.86,;8.18,-9.09,;8.18,-7.54,;9.51,-6.77,;10.84,-7.54,;12.32,-7.06,;13.23,-8.31,;12.32,-9.57,;13.07,-10.91,;14.6,-10.93,;15.35,-12.29,;14.55,-13.61,;15.29,-14.96,;13.01,-13.57,;12.27,-12.23,;10.84,-9.09,;9.51,-9.86,;13.03,-5.69,;12.21,-4.4,;12.91,-3.04,;14.46,-2.97,;15.28,-4.27,;14.57,-5.63,;16.82,-4.21,;17.54,-2.84,;17.65,-5.51,;16.93,-6.87,)| | ||
| Structure | 
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