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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50469367 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1804040 (CHEMBL4276332) | ||
| IC50 | 4.1±n/a nM | ||
| Citation |  Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM50469367 | |||
| n/a | |||
| Name | BDBM50469367 | ||
| Synonyms: | CHEMBL4294601 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H44N6O | ||
| Mol. Mass. | 504.71 | ||
| SMILES | CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CC[C@@H](C2)N(C)C)cc1 |r,wU:13.12,30.35,wD:16.16,3.3,(-.72,-25.42,;.63,-24.65,;1.96,-25.42,;3.29,-24.65,;3.29,-23.11,;4.63,-25.42,;5.96,-24.65,;5.96,-23.11,;7.29,-22.34,;8.63,-23.1,;10.1,-22.62,;11.01,-23.88,;10.1,-25.13,;10.85,-26.47,;12.39,-26.5,;13.13,-27.85,;12.33,-29.17,;13.07,-30.52,;10.79,-29.14,;10.05,-27.79,;8.63,-24.65,;7.3,-25.42,;10.82,-21.26,;12.36,-21.2,;13.07,-19.84,;12.24,-18.53,;12.95,-17.17,;14.49,-17.1,;15.45,-18.3,;16.9,-17.76,;16.83,-16.22,;15.35,-15.81,;18.04,-15.26,;19.47,-15.83,;17.81,-13.74,;10.7,-18.6,;9.99,-19.97,)| | ||
| Structure | 
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