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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50469368 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1804040 (CHEMBL4276332) | ||
| IC50 | 3.5±n/a nM | ||
| Citation |  Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM50469368 | |||
| n/a | |||
| Name | BDBM50469368 | ||
| Synonyms: | CHEMBL4284392 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H39FN6O3S | ||
| Mol. Mass. | 558.711 | ||
| SMILES | CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1F)S(=O)(=O)N1CCN(C)CC1 |r,wU:13.12,wD:16.16,3.3,(.63,-11.6,;1.96,-10.83,;3.3,-11.6,;4.63,-10.83,;4.63,-9.29,;5.96,-11.6,;7.3,-10.83,;7.3,-9.29,;8.63,-8.52,;9.96,-9.28,;11.44,-8.8,;12.35,-10.05,;11.44,-11.31,;12.19,-12.65,;13.72,-12.67,;14.47,-14.03,;13.67,-15.35,;14.41,-16.7,;12.13,-15.31,;11.39,-13.97,;9.96,-10.83,;8.63,-11.6,;12.15,-7.44,;13.69,-7.38,;14.41,-6.01,;13.58,-4.71,;12.03,-4.78,;11.33,-6.15,;9.79,-6.21,;14.29,-3.34,;12.95,-2.57,;14.28,-1.8,;15.83,-3.28,;16.65,-4.59,;18.19,-4.53,;18.91,-3.16,;20.45,-3.1,;18.09,-1.86,;16.54,-1.92,)| | ||
| Structure | 
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