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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50469357 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1804040 (CHEMBL4276332) | ||
| IC50 | 4.3±n/a nM | ||
| Citation |  Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM50469357 | |||
| n/a | |||
| Name | BDBM50469357 | ||
| Synonyms: | CHEMBL4287582 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H42N6O | ||
| Mol. Mass. | 490.6834 | ||
| SMILES | CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1 |r,wU:13.12,wD:16.16,3.3,(.92,-10.8,;2.25,-10.03,;3.58,-10.8,;4.92,-10.04,;4.92,-8.5,;6.25,-10.81,;7.59,-10.04,;7.59,-8.49,;8.92,-7.72,;10.25,-8.49,;11.73,-8.01,;12.64,-9.26,;11.73,-10.51,;12.47,-11.86,;14.01,-11.88,;14.75,-13.24,;13.96,-14.56,;14.7,-15.91,;12.42,-14.52,;11.68,-13.18,;10.25,-10.04,;8.92,-10.81,;12.44,-6.64,;13.98,-6.58,;14.69,-5.22,;13.87,-3.92,;14.58,-2.55,;16.12,-2.49,;16.94,-3.79,;18.47,-3.73,;19.19,-2.37,;20.73,-2.31,;18.37,-1.07,;16.82,-1.13,;12.32,-3.99,;11.62,-5.35,)| | ||
| Structure | 
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