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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50469376 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1804040 (CHEMBL4276332) | ||
| IC50 | 1.3±n/a nM | ||
| Citation |  Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
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| BDBM50469376 | |||
| n/a | |||
| Name | BDBM50469376 | ||
| Synonyms: | CHEMBL4284541 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H42N6O | ||
| Mol. Mass. | 502.6941 | ||
| SMILES | CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1(CC1)N1CCN(C)CC1 |r,wU:12.11,wD:15.15,(16.6,-19.72,;16.59,-21.26,;17.92,-22.04,;19.25,-21.27,;20.58,-22.04,;21.91,-21.27,;21.91,-19.73,;23.24,-18.96,;24.58,-19.72,;26.05,-19.24,;26.96,-20.49,;26.05,-21.75,;26.8,-23.09,;28.33,-23.11,;29.08,-24.47,;28.28,-25.78,;29.02,-27.13,;26.74,-25.75,;26,-24.41,;24.58,-21.27,;23.25,-22.04,;26.76,-17.88,;28.3,-17.82,;29.01,-16.45,;28.19,-15.15,;26.64,-15.22,;25.94,-16.59,;28.9,-13.79,;27.4,-13.38,;28.5,-12.29,;30.44,-13.72,;31.26,-15.03,;32.79,-14.97,;33.51,-13.6,;35.05,-13.54,;32.69,-12.3,;31.14,-12.36,)| | ||
| Structure | 
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