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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50469369 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1804040 (CHEMBL4276332) | ||
| IC50 | 4.9±n/a nM | ||
| Citation |  Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
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| BDBM50469369 | |||
| n/a | |||
| Name | BDBM50469369 | ||
| Synonyms: | CHEMBL4295042 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H40N6O | ||
| Mol. Mass. | 476.6568 | ||
| SMILES | CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCNCC2)cc1 |r,wU:13.12,wD:16.16,3.3,(18.56,-12.04,;19.89,-11.27,;21.22,-12.04,;22.56,-11.27,;22.56,-9.73,;23.89,-12.04,;25.22,-11.27,;25.23,-9.73,;26.55,-8.96,;27.89,-9.72,;29.36,-9.24,;30.28,-10.5,;29.37,-11.75,;30.11,-13.09,;31.65,-13.12,;32.39,-14.47,;31.59,-15.79,;32.33,-17.14,;30.05,-15.76,;29.31,-14.41,;27.89,-11.27,;26.56,-12.04,;30.08,-7.88,;31.62,-7.82,;32.33,-6.46,;31.5,-5.15,;32.21,-3.79,;33.75,-3.72,;34.58,-5.03,;36.12,-4.97,;36.84,-3.61,;36.01,-2.3,;34.46,-2.36,;29.96,-5.22,;29.25,-6.59,)| | ||
| Structure | 
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