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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase receptor TYRO3 | ||
| Ligand | BDBM50469366 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1804042 (CHEMBL4276334) | ||
| IC50 | 6.7±n/a nM | ||
| Citation |  Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem61:10242-10254 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase receptor TYRO3 | |||
| Name: | Tyrosine-protein kinase receptor TYRO3 | ||
| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY | ||
| Type: | Protein | ||
| Mol. Mass.: | 96894.13 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06418 | ||
| Residue: | 890 | ||
| Sequence: |
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| BDBM50469366 | |||
| n/a | |||
| Name | BDBM50469366 | ||
| Synonyms: | CHEMBL4282624 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H42N6O | ||
| Mol. Mass. | 490.6834 | ||
| SMILES | CCCC(C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1 |r,wU:13.12,wD:16.16,(1.79,-13.98,;3.12,-13.21,;4.46,-13.99,;5.79,-13.22,;5.79,-11.68,;7.12,-13.99,;8.46,-13.22,;8.46,-11.67,;9.79,-10.9,;11.12,-11.67,;12.6,-11.19,;13.51,-12.44,;12.6,-13.7,;13.35,-15.04,;14.88,-15.06,;15.63,-16.42,;14.83,-17.74,;15.57,-19.09,;13.29,-17.7,;12.55,-16.36,;11.12,-13.22,;9.79,-13.99,;13.31,-9.82,;14.85,-9.76,;15.56,-8.4,;14.74,-7.1,;15.45,-5.73,;16.99,-5.67,;17.81,-6.97,;19.34,-6.91,;20.06,-5.55,;21.6,-5.49,;19.24,-4.25,;17.7,-4.31,;13.19,-7.17,;12.49,-8.53,)| | ||
| Structure | 
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