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TargetThymidine kinase
LigandBDBM50472229
Substrate/Competitorn/a
Meas. Tech.ChEMBL_61074 (CHEMBL674914)
EC50 914000±n/a nM
Citation Holý, AGünter, JDvoráková, HMasojídková, MAndrei, GSnoeck, RBalzarini, JDe Clercq, E Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. J Med Chem42:2064-86 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidine kinase
Name:Thymidine kinase
Synonyms:KITH_HHV1S | TK | Thymidine kinase | UL23
Type:PROTEIN
Mol. Mass.:40883.42
Organism:Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1)
Description:ChEMBL_213
Residue:376
Sequence:
MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPGSIPT
ICDLARTFAREMGEAN
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BDBM50472229
n/a
NameBDBM50472229
Synonyms:CHEMBL63849
TypeSmall organic molecule
Emp. Form.C7H11BrN3O5P
Mol. Mass.328.057
SMILESNc1nc(=O)n(CCOCP(O)(O)=O)cc1Br
Structure
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