Reaction Details |
| Report a problem with these data |
Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
---|
Ligand | BDBM50473075 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_216751 (CHEMBL820636) |
---|
IC50 | 340±n/a nM |
---|
Citation | Burnouf, C; Auclair, E; Avenel, N; Bertin, B; Bigot, C; Calvet, A; Chan, K; Durand, C; Fasquelle, V; Féru, F; Gilbertsen, R; Jacobelli, H; Kebsi, A; Lallier, E; Maignel, J; Martin, B; Milano, S; Ouagued, M; Pascal, Y; Pruniaux, MP; Puaud, J; Rocher, MN; Terrasse, C; Wrigglesworth, R; Doherty, AM Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors. J Med Chem43:4850-67 (2000) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
---|
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
Type: | PROTEIN |
Mol. Mass.: | 60038.21 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_104732 |
Residue: | 536 |
Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
|
|
|
BDBM50473075 |
---|
n/a |
---|
Name | BDBM50473075 |
Synonyms: | CHEMBL343243 |
Type | Small organic molecule |
Emp. Form. | C23H20N6O2 |
Mol. Mass. | 412.4439 |
SMILES | Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1N)C3=O)c1ccccc1 |c:12| |
Structure |
|