Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | ||
Ligand | BDBM50346088 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_216751 (CHEMBL820636) | ||
IC50 | 49±n/a nM | ||
Citation | Burnouf, C; Auclair, E; Avenel, N; Bertin, B; Bigot, C; Calvet, A; Chan, K; Durand, C; Fasquelle, V; Féru, F; Gilbertsen, R; Jacobelli, H; Kebsi, A; Lallier, E; Maignel, J; Martin, B; Milano, S; Ouagued, M; Pascal, Y; Pruniaux, MP; Puaud, J; Rocher, MN; Terrasse, C; Wrigglesworth, R; Doherty, AM Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors. J Med Chem43:4850-67 (2000) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4C | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | ||
Synonyms: | Dpde1 | PDE4C_RAT | Pde4c | ||
Type: | PROTEIN | ||
Mol. Mass.: | 60038.21 | ||
Organism: | Rattus norvegicus | ||
Description: | ChEMBL_104732 | ||
Residue: | 536 | ||
Sequence: |
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BDBM50346088 | |||
n/a | |||
Name | BDBM50346088 | ||
Synonyms: | (1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid | 4-Cyano-3-cyclopentyloxy-4-(4-methoxy-phenyl)-cyclohexanecarboxylic acid | 4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid | 4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid (Ariflo) | 4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid methyl ester | 4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid(Ariflo) | 6-(3,4-Dimethoxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one | Ariflo | CHEMBL511115 | SB-207499 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H25NO4 | ||
Mol. Mass. | 343.4168 | ||
SMILES | COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N |r,wU:17.22,14.25,(4.79,2.97,;3.46,3.74,;2.12,2.97,;.79,3.74,;-.54,2.97,;-.54,1.43,;.79,.66,;2.12,1.43,;3.46,.66,;3.46,-.88,;4.7,-1.79,;4.23,-3.25,;2.69,-3.25,;2.21,-1.79,;-1.88,.66,;-3.42,.71,;-4.23,-.6,;-3.51,-1.96,;-1.97,-2.01,;-1.16,-.7,;-4.33,-3.26,;-3.6,-4.62,;-5.87,-3.21,;-1.77,2.19,;-1.66,3.73,)| | ||
Structure |