| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 1/2 |
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| Ligand | BDBM50169048 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_312518 (CHEMBL833397) |
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| IC50 | 34±n/a nM |
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| Citation |  Allegretti, M; Bertini, R; Cesta, MC; Bizzarri, C; Di Bitondo, R; Di Cioccio, V; Galliera, E; Berdini, V; Topai, A; Zampella, G; Russo, V; Di Bello, N; Nano, G; Nicolini, L; Locati, M; Fantucci, P; Florio, S; Colotta, F 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem48:4312-31 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 1/2 |
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| Name: | C-X-C chemokine receptor type 1/2 |
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| Synonyms: | Interleukin-8 receptors, CXCR1/CXCR2 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 89096 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | C-X-C chemokine receptor type 1 |
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| Synonyms: | C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39803.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25024 |
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| Residue: | 350 |
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| Sequence: | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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| Component 2 |
| Name: | C-X-C chemokine receptor type 2 |
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| Synonyms: | C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B |
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| Type: | Protein |
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| Mol. Mass.: | 40767.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25025 |
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| Residue: | 360 |
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| Sequence: | MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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| BDBM50169048 |
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| n/a |
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| Name | BDBM50169048 |
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| Synonyms: | (R)-2-(3-Benzoyl-phenyl)-propionic acid | (R)-2-(3-Benzoylphenyl)propionic acid | (R)-2-(3-benzoylphenyl)propanoic acid | CHEMBL372052 | KETOPROFEN |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14O3 |
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| Mol. Mass. | 254.2806 |
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| SMILES | C[C@@H](C(O)=O)c1cccc(c1)C(=O)c1ccccc1 |
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| Structure | 
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