Reaction Details |
| Report a problem with these data |
Target | Presenilin-1 |
---|
Ligand | BDBM50477515 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_455939 (CHEMBL887940) |
---|
IC50 | 162±n/a nM |
---|
Citation | Prasad, CV; Zheng, M; Vig, S; Bergstrom, C; Smith, DW; Gao, Q; Yeola, S; Polson, CT; Corsa, JA; Guss, VL; Loo, A; Wang, J; Sleczka, BG; Dangler, C; Robertson, BJ; Hendrick, JP; Roberts, SB; Barten, DM Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease. Bioorg Med Chem Lett17:4006-11 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Presenilin-1 |
---|
Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
|
|
|
BDBM50477515 |
---|
n/a |
---|
Name | BDBM50477515 |
Synonyms: | CHEMBL246371 |
Type | Small organic molecule |
Emp. Form. | C20H21N5O3 |
Mol. Mass. | 379.4124 |
SMILES | C[C@H](NC(=O)Cc1cccnc1)C(=O)NC1c2ccccc2C=NN(C)C1=O |c:24| |
Structure |
|