| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50477522 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_455939 (CHEMBL887940) |
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| IC50 | 750±n/a nM |
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| Citation |  Prasad, CV; Zheng, M; Vig, S; Bergstrom, C; Smith, DW; Gao, Q; Yeola, S; Polson, CT; Corsa, JA; Guss, VL; Loo, A; Wang, J; Sleczka, BG; Dangler, C; Robertson, BJ; Hendrick, JP; Roberts, SB; Barten, DM Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease. Bioorg Med Chem Lett17:4006-11 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50477522 |
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| n/a |
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| Name | BDBM50477522 |
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| Synonyms: | CHEMBL393484 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20F2N4O4 |
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| Mol. Mass. | 430.4047 |
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| SMILES | [H][C@@]1(NC(=O)[C@H](C)NC(=O)[C@H](O)c2cc(F)cc(F)c2)c2ccccc2C=NN(C)C1=O |c:28| |
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| Structure | 
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