| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50478793 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_530350 (CHEMBL968446) |
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| IC50 | 266000±n/a nM |
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| Citation |  Stefek, M; Snirc, V; Djoubissie, PO; Majekova, M; Demopoulos, V; Rackova, L; Bezakova, Z; Karasu, C; Carbone, V; El-Kabbani, O Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling. Bioorg Med Chem16:4908-20 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35797.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1512484 |
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| Residue: | 316 |
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| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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| BDBM50478793 |
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| n/a |
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| Name | BDBM50478793 |
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| Synonyms: | CHEMBL479175 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N2NaO2 |
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| Mol. Mass. | 344.3827 |
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| SMILES | [Na;v0+].[H][C@]12[#6]-[#6]-[#7](-[#6]-c3ccccc3)-[#6][C@@]1([H])c1cc(-[#6]-[#6](-[#8-])=O)ccc1-[#7]2 |r| |
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| Structure | 
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