| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
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| Ligand | BDBM50276157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_553938 (CHEMBL962871) |
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| IC50 | 4400±n/a nM |
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| Citation |  Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. J Nat Prod71:972-80 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src |
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| Name: | Proto-oncogene tyrosine-protein kinase Src |
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| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src |
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| Type: | Protein |
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| Mol. Mass.: | 59838.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P12931 |
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| Residue: | 536 |
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| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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| BDBM50276157 |
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| n/a |
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| Name | BDBM50276157 |
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| Synonyms: | Alternariol 5-O-Methyl Ether | CHEMBL483526 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12O5 |
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| Mol. Mass. | 272.2528 |
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| SMILES | COc1cc(O)c2c(c1)c1c(C)cc(O)cc1oc2=O |
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| Structure | 
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