Ki Summary

Reaction Details

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Target

RNA-directed RNA polymerase

Ligand

BDBM50537584

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1969960 (CHEMBL4602778)

IC50

53±n/a nM

Citation

Ganta, NM; Gedda, G; Rathnakar, B; Satyanarayana, M; Yamajala, B; Ahsan, MJ; Jadav, SS; Balaraju, T A review on HCV inhibitors: Significance of non-structural polyproteins. Eur J Med Chem164:576-601 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

RNA-directed RNA polymerase

Name:

RNA-directed RNA polymerase

Synonyms:

Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein

Type:

Protein

Mol. Mass.:

25173.95

Organism:

Hepatitis C virus

Description:

Q8JXU8

Residue:

229

Sequence:

RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ

BDBM50537584

n/a

Name

BDBM50537584

Synonyms:

CHEMBL4636786

Type

Small organic molecule

Emp. Form.

C20H15ClN4O3

Mol. Mass.

394.811

SMILES

Nc1cc(Cn2c(C(O)=O)c(-c3ccc[nH]c3=O)c3ccc(Cl)cc23)ccn1 |(7.03,-10.36,;7.79,-11.7,;9.33,-11.72,;10.07,-13.06,;11.62,-13.08,;12.4,-11.75,;13.93,-11.91,;14.71,-13.24,;13.94,-14.58,;16.25,-13.24,;14.55,-10.5,;16.05,-10.18,;17.09,-11.33,;18.59,-11,;19.07,-9.54,;18.03,-8.39,;16.52,-8.71,;15.49,-7.57,;13.41,-9.48,;13.4,-7.93,;12.06,-7.16,;10.73,-7.93,;9.4,-7.16,;10.73,-9.48,;12.08,-10.25,;9.3,-14.39,;7.76,-14.38,;7,-13.03,)|

Structure