Ki Summary

Reaction Details

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Target

RNA-directed RNA polymerase

Ligand

BDBM50537585

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1969960 (CHEMBL4602778)

IC50

5.0±n/a nM

Citation

Ganta, NM; Gedda, G; Rathnakar, B; Satyanarayana, M; Yamajala, B; Ahsan, MJ; Jadav, SS; Balaraju, T A review on HCV inhibitors: Significance of non-structural polyproteins. Eur J Med Chem164:576-601 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

RNA-directed RNA polymerase

Name:

RNA-directed RNA polymerase

Synonyms:

Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein

Type:

Protein

Mol. Mass.:

25173.95

Organism:

Hepatitis C virus

Description:

Q8JXU8

Residue:

229

Sequence:

RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ

BDBM50537585

n/a

Name

BDBM50537585

Synonyms:

CHEMBL4646449

Type

Small organic molecule

Emp. Form.

C25H21F2N3O4S

Mol. Mass.

497.514

SMILES

Cc1ccc2c(c(C(=O)NS(=O)(=O)C3CC3)n(Cc3cc(F)ccc3F)c2c1)-c1ccc[nH]c1=O |(25.71,-7.97,;27.04,-8.74,;28.37,-7.96,;29.71,-8.73,;29.71,-10.28,;30.86,-11.3,;30.24,-12.71,;31.01,-14.04,;32.55,-14.03,;30.25,-15.38,;31.02,-16.7,;32.35,-15.92,;32.36,-17.46,;30.26,-18.04,;28.93,-18.82,;30.27,-19.59,;28.71,-12.55,;27.92,-13.88,;26.38,-13.86,;25.64,-12.52,;24.1,-12.5,;23.34,-11.16,;23.31,-13.83,;24.07,-15.17,;25.61,-15.18,;26.37,-16.52,;28.39,-11.05,;27.04,-10.28,;32.36,-10.98,;33.39,-12.12,;34.89,-11.8,;35.37,-10.34,;34.34,-9.19,;32.82,-9.51,;31.79,-8.37,)|

Structure