Ki Summary

Reaction Details

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Target

RNA-directed RNA polymerase

Ligand

BDBM50379197

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1969960 (CHEMBL4602778)

IC50

8.0±n/a nM

Citation

Ganta, NM; Gedda, G; Rathnakar, B; Satyanarayana, M; Yamajala, B; Ahsan, MJ; Jadav, SS; Balaraju, T A review on HCV inhibitors: Significance of non-structural polyproteins. Eur J Med Chem164:576-601 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

RNA-directed RNA polymerase

Name:

RNA-directed RNA polymerase

Synonyms:

Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein

Type:

Protein

Mol. Mass.:

25173.95

Organism:

Hepatitis C virus

Description:

Q8JXU8

Residue:

229

Sequence:

RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ

BDBM50379197

n/a

Name

BDBM50379197

Synonyms:

CHEMBL2011266

Type

Small organic molecule

Emp. Form.

C25H20F3N3O4S

Mol. Mass.

515.504

SMILES

Cc1cc2c(c(C(=O)NS(=O)(=O)C3CC3)n(Cc3cc(F)ccc3F)c2cc1F)-c1ccc[nH]c1=O |(35.01,-44.88,;36.34,-45.65,;37.67,-44.88,;39.01,-45.64,;40.48,-45.16,;41.39,-46.42,;42.74,-47.16,;44.06,-46.37,;42.76,-48.7,;44.11,-49.45,;44.87,-48.11,;45.65,-49.44,;44.13,-50.99,;43.39,-52.34,;44.93,-52.31,;40.48,-47.67,;41.29,-48.98,;40.56,-50.34,;39.02,-50.38,;38.29,-51.73,;36.75,-51.78,;39.1,-53.04,;40.65,-52.99,;41.37,-51.64,;42.91,-51.59,;39.01,-47.19,;37.68,-47.96,;36.34,-47.19,;35.01,-47.96,;41.25,-43.83,;40.48,-42.5,;41.23,-41.17,;42.78,-41.16,;43.56,-42.49,;42.79,-43.82,;43.57,-45.15,)|

Structure