Ki Summary

Reaction Details

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Target

RNA-directed RNA polymerase

Ligand

BDBM50537586

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1969960 (CHEMBL4602778)

IC50

39±n/a nM

Citation

Ganta, NM; Gedda, G; Rathnakar, B; Satyanarayana, M; Yamajala, B; Ahsan, MJ; Jadav, SS; Balaraju, T A review on HCV inhibitors: Significance of non-structural polyproteins. Eur J Med Chem164:576-601 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

RNA-directed RNA polymerase

Name:

RNA-directed RNA polymerase

Synonyms:

Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein

Type:

Protein

Mol. Mass.:

25173.95

Organism:

Hepatitis C virus

Description:

Q8JXU8

Residue:

229

Sequence:

RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ

BDBM50537586

n/a

Name

BDBM50537586

Synonyms:

CHEMBL4641917

Type

Small organic molecule

Emp. Form.

C27H23ClN6O6S2

Mol. Mass.

627.091

SMILES

CS(=O)(=O)Nc1cccc(c1)S(=O)(=O)NC(=O)c1c(-c2ccc[nH]c2=O)c2ccc(Cl)cc2n1Cc1ccnc(N)c1 |(15.23,-36.58,;14.44,-35.25,;14.44,-33.71,;15.77,-34.47,;12.91,-35.27,;12.13,-33.95,;10.57,-33.96,;9.79,-32.62,;10.56,-31.28,;12.1,-31.28,;12.88,-32.6,;12.87,-29.94,;14.2,-29.16,;14.2,-30.7,;12.09,-28.61,;12.86,-27.28,;14.4,-27.27,;12.08,-25.95,;12.7,-24.54,;14.2,-24.22,;15.24,-25.36,;16.73,-25.04,;17.21,-23.58,;16.18,-22.43,;14.67,-22.75,;13.64,-21.61,;11.56,-23.52,;11.55,-21.97,;10.22,-21.2,;8.89,-21.97,;7.55,-21.2,;8.89,-23.52,;10.23,-24.29,;10.55,-25.79,;9.77,-27.12,;8.23,-27.1,;7.46,-28.42,;5.92,-28.41,;5.16,-27.06,;5.94,-25.74,;5.19,-24.4,;7.48,-25.76,)|

Structure