Ki Summary

Reaction Details

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Target

RNA-directed RNA polymerase

Ligand

BDBM50537587

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1969960 (CHEMBL4602778)

IC50

6.0±n/a nM

Citation

Ganta, NM; Gedda, G; Rathnakar, B; Satyanarayana, M; Yamajala, B; Ahsan, MJ; Jadav, SS; Balaraju, T A review on HCV inhibitors: Significance of non-structural polyproteins. Eur J Med Chem164:576-601 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

RNA-directed RNA polymerase

Name:

RNA-directed RNA polymerase

Synonyms:

Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein

Type:

Protein

Mol. Mass.:

25173.95

Organism:

Hepatitis C virus

Description:

Q8JXU8

Residue:

229

Sequence:

RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ

BDBM50537587

n/a

Name

BDBM50537587

Synonyms:

CHEMBL4633142

Type

Small organic molecule

Emp. Form.

C25H21F2N3O5S

Mol. Mass.

513.513

SMILES

CC1COc2cc3c(c(C(=O)NS(C)(=O)=O)n(Cc4cc(F)ccc4F)c3cc12)-c1ccc[nH]c1=O |(21.41,-24.4,;22.91,-24.06,;23.53,-22.66,;25.05,-22.81,;25.38,-24.31,;26.73,-25.08,;26.73,-26.63,;27.88,-27.65,;27.26,-29.06,;28.03,-30.39,;29.57,-30.39,;27.27,-31.73,;28.04,-33.05,;27.27,-34.4,;29.37,-32.28,;29.38,-33.82,;25.73,-28.9,;24.94,-30.23,;23.4,-30.21,;22.65,-28.87,;21.11,-28.85,;20.36,-27.51,;20.32,-30.18,;21.09,-31.53,;22.63,-31.54,;23.39,-32.88,;25.4,-27.4,;24.06,-26.63,;24.06,-25.08,;29.38,-27.33,;30.41,-28.47,;31.91,-28.15,;32.39,-26.69,;31.36,-25.54,;29.85,-25.86,;28.81,-24.72,)|

Structure