| Reaction Details |
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 | Report a problem with these data |
| Target | Sepiapterin reductase |
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| Ligand | BDBM50537633 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1970294 (CHEMBL4603112) |
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| IC50 | 3236±n/a nM |
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| Citation |  Gao, H; Schneider, S; Andrews, P; Wang, K; Huang, X; Sparling, BA Virtual screening to identify potent sepiapterin reductase inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sepiapterin reductase |
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| Name: | Sepiapterin reductase |
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| Synonyms: | SPR | SPRE_HUMAN | Sepiapterin reductase (SPR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 28050.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35270 |
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| Residue: | 261 |
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| Sequence: | MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG
LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV
NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML
FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK
LLSLLEKDEFKSGAHVDFYDK
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| BDBM50537633 |
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| n/a |
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| Name | BDBM50537633 |
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| Synonyms: | CHEMBL4635573 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N2O4 |
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| Mol. Mass. | 378.4211 |
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| SMILES | CC1(C)C(O)=C(C(N)=O)C(=O)c2cc(ccc12)C(=O)NCCc1ccccc1 |t:4| |
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| Structure | 
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