| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil collagenase |
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| Ligand | BDBM50031771 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_49517 (CHEMBL660241) |
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| Ki | 32±n/a nM |
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| Citation |  Gowravaram, MR; Tomczuk, BE; Johnson, JS; Delecki, D; Cook, ER; Ghose, AK; Mathiowetz, AM; Spurlino, JC; Rubin, B; Smith, DL Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group. J Med Chem38:2570-81 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil collagenase |
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| Name: | Neutrophil collagenase |
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| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
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| Type: | Enzyme |
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| Mol. Mass.: | 53413.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22894 |
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| Residue: | 467 |
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| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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| BDBM50031771 |
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| n/a |
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| Name | BDBM50031771 |
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| Synonyms: | (R)-3-((S)-1-Methylcarbamoyl-2-phenyl-ethylcarbamoyl)-heptanedioic acid 1-hydroxyamide 7-(phenethyl-amide) | (R)-N1-hydroxy-N2-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-N5-phenethylpentane-1,2,5-tricarboxamide | CHEMBL86797 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34N4O5 |
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| Mol. Mass. | 482.572 |
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| SMILES | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCC(=O)NCCc1ccccc1)CC(=O)NO |
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| Structure | 
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