| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50031834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_202094 (CHEMBL813351) |
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| IC50 | 105.9±n/a nM |
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| Citation |  Magnin, DR; Biller, SA; Dickson, JK; Logan, JV; Lawrence, RM; Chen, Y; Sulsky, RB; Ciosek, CP; Harrity, TW; Jolibois, KG 1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate. J Med Chem38:2596-605 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48109.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1336736 |
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| Residue: | 416 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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| BDBM50031834 |
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| n/a |
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| Name | BDBM50031834 |
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| Synonyms: | CHEMBL86919 | [(3E,7E)-1-(Hydroxy-methyl-phosphinoyl)-4,8,12-trimethyl-trideca-3,7,11-trienyl]-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C17H32O5P2 |
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| Mol. Mass. | 378.3805 |
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| SMILES | [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6]-[#6]=[#6](P([#6])([#8])=O)P([#8])([#8])=O |w:14.13| |
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| Structure | 
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