| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50489259 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934758 (CHEMBL2318645) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Johns, BA; Kawasuji, T; Weatherhead, JG; Boros, EE; Thompson, JB; Koble, CS; Garvey, EP; Foster, SA; Jeffrey, JL; Fujiwara, T Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups. Bioorg Med Chem Lett23:422-5 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50489259 |
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| n/a |
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| Name | BDBM50489259 |
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| Synonyms: | CHEMBL2315832 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23FN4O5S |
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| Mol. Mass. | 462.495 |
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| SMILES | CN(CCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(C)c1=O)S(C)(=O)=O |
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| Structure | 
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