| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Integrase |
|---|
| Ligand | BDBM64732 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_940681 (CHEMBL2327747) |
|---|
| IC50 | >20000±n/a nM |
|---|
| Citation |  Serrao, E; Debnath, B; Otake, H; Kuang, Y; Christ, F; Debyser, Z; Neamati, N Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction. J Med Chem56:2311-22 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Integrase |
|---|
| Name: | Integrase |
|---|
| Synonyms: | pol |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 32203.43 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_106649 |
|---|
| Residue: | 288 |
|---|
| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
|
|
|
|---|
| BDBM64732 |
|---|
| n/a |
|---|
| Name | BDBM64732 |
|---|
| Synonyms: | MLS001204078 | N-[(8-Hydroxy-quinolin-7-yl)-phenyl-methyl]-butyramide | N-[(8-hydroxy-7-quinolinyl)-phenylmethyl]butanamide | N-[(8-hydroxy-7-quinolyl)-phenyl-methyl]butyramide | N-[(8-hydroxyquinolin-7-yl)-phenylmethyl]butanamide | N-[(8-oxidanylquinolin-7-yl)-phenyl-methyl]butanamide | SMR000516558 | cid_2876668 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20N2O2 |
|---|
| Mol. Mass. | 320.385 |
|---|
| SMILES | CCCC(=O)NC(c1ccccc1)c1ccc2cccnc2c1O |
|---|
| Structure | 
|
|---|
Search and Browse
