| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50492117 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_969007 (CHEMBL2400596) |
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| IC50 | 1300±n/a nM |
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| Citation |  Masaoka, T; Chung, S; Caboni, P; Rausch, JW; Wilson, JA; Taskent-Sezgin, H; Beutler, JA; Tocco, G; Le Grice, SF Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J Med Chem56:5436-45 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50492117 |
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| n/a |
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| Name | BDBM50492117 |
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| Synonyms: | CHEMBL2397278 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11F3N2OS |
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| Mol. Mass. | 324.321 |
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| SMILES | Cc1sc2nc([nH]c(=O)c2c1C)-c1ccc(cc1)C(F)(F)F |
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| Structure | 
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