Reaction Details |
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Target | Squalene synthase |
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Ligand | BDBM50037279 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_202098 (CHEMBL814033) |
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IC50 | 8±n/a nM |
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Citation | Procopiou, PA; Bailey, EJ; Bamford, MJ; Craven, AP; Dymock, BW; Houston, JG; Hutson, JL; Kirk, BE; McCarthy, AD; Sareen, M The squalestatins: novel inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C1-modified analogues. J Med Chem37:3274-81 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Squalene synthase |
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Name: | Squalene synthase |
Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
Type: | PROTEIN |
Mol. Mass.: | 48109.41 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1336736 |
Residue: | 416 |
Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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BDBM50037279 |
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n/a |
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Name | BDBM50037279 |
Synonyms: | (1S,3S,4S,5R,6R,7R)-6-((4R,6S)-4,6-Dimethyl-octanoyloxy)-4,7-dihydroxy-1-((4S,5S)-4-hydroxy-3,5-dimethyl-6-phenyl-hexyl)-2,8-dioxa-bicyclo[3.2.1]octane-3,4,5-tricarboxylic acid | CHEMBL324526 |
Type | Small organic molecule |
Emp. Form. | C33H48O13 |
Mol. Mass. | 652.7264 |
SMILES | CC[C@H](C)C[C@H](C)CCC(=O)O[C@@H]1[C@@H](O)[C@]2(CCC(C)[C@H](O)[C@@H](C)Cc3ccccc3)O[C@@]1(C(O)=O)[C@@](O)([C@H](O2)C(O)=O)C(O)=O |
Structure |
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