Reaction Details |
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Target | Reverse transcriptase |
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Ligand | BDBM50492335 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_969194 (CHEMBL2404614) |
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IC50 | 11640±n/a nM |
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Citation | Yang, S; Pannecouque, C; Daelemans, D; Ma, XD; Liu, Y; Chen, FE; De Clercq, E Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem65:134-43 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase |
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Name: | Reverse transcriptase |
Synonyms: | n/a |
Type: | Protein |
Mol. Mass.: | 29598.37 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WKE8 |
Residue: | 254 |
Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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BDBM50492335 |
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n/a |
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Name | BDBM50492335 |
Synonyms: | CHEMBL2402961 |
Type | Small organic molecule |
Emp. Form. | C21H20N4O2 |
Mol. Mass. | 360.4091 |
SMILES | COCCc1ccc(Oc2cc(C)nc(Nc3ccc(cc3)C#N)n2)cc1 |
Structure |
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