Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50037771 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_209593 (CHEMBL814728) |
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IC50 | 300±n/a nM |
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Citation | Cozzi, P; Giordani, A; Menichincheri, M; Pillan, A; Pinciroli, V; Rossi, A; Tonani, R; Volpi, D; Tamburin, M; Ferrario, R Agents combining thromboxane receptor antagonism with thromboxane synthase inhibition: [[[2-(1H-imidazol-1-yl)ethylidene]amino]oxy]alkanoic acids. J Med Chem37:3588-604 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50037771 |
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n/a |
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Name | BDBM50037771 |
Synonyms: | 5-[1-Cyclohexyl-3-(2-fluoro-phenyl)-2-imidazol-1-yl-prop-(E)-ylideneaminooxy]-pentanoic acid | CHEMBL333236 |
Type | Small organic molecule |
Emp. Form. | C23H30FN3O3 |
Mol. Mass. | 415.501 |
SMILES | OC(=O)CCCCO\N=C(\C(Cc1ccccc1F)n1ccnc1)C1CCCCC1 |
Structure |
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